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It can be caused by genetics, stress, hormonal imbalances, nutritional deficiencies, or underlying medical conditions

Studies show that the ingestion of glutathione can enhance skin whitening and reduce the skin's pigmentation in certain people, but the effects tend to be mild as opposed to being extreme

Nicotinamide N-Methyltransferase Knockdown Protects against Diet-Induced Obesity

Plant Cell 10:267282 Lu YP, Li ZS, Drozdowicz YM, Hortensteiner S, Martinoia E, Rea PA (1998b) AtMRP2 and Arabidopsis ATP binding cassette transporter able to transport glutathione S-conjugates and chlorophyll catabolites: functional comparisons with AtMRP1

As a powerful antioxidant, L-Glutathione protects cells from damage caused by oxidative stress and free radicals